Impact of Pathological Complete Response in Breast Cancer Following Neoadjuvant Therapy on Patient’s Outcome

Rufina Soomro (1), Rabab Zehra (2)
(1) Liaquat national Hospital and Medical College, Karachi, Pakistan, Pakistan,
(2) Liaquat National Hospital and Medical College, Karachi. Pakistan, Pakistan

Abstract

Background: Patients who achieve a pathological complete response (pCR) after neoadjuvant therapy have better outcomes than patients with residual disease. Despite the excellent prognosis associated with achieving a pCR, recurrence still occurs. The study was conducted with the intent to evaluate factors associated with tumor recurrence and survival among patients achieving pCR after neoadjuvant therapy.


Methods: We evaluated the medical records of patients with breast cancer who received neoadjuvant therapy and achieved pCR in our academic institute. The survival curve was estimated with the Kaplan-Meier method in patients who developed recurrence.


Results: In our retrospective study 2,360 received neoadjuvant therapy out of which 315 (13.3%) who achieved pCR were included in this study. The mean age was 45.85 (range 21-92 years) and the mean duration of follow-up was 41.2 months. The clinical tumor stage T1-T2 represented 55%, T3-T4 was 44.1%, and node-positive was 54%. The primary endpoint was the correlation between pCR achieved after neoadjuvant therapy and disease-free survival or overall survival. . Predictors of pCR were clinical T-stage and receiving appropriate chemotherapy. We observed that patients who had an increased risk of recurrence after achieving pCR were those with clinical stage III-IV, patients with mastectomy, and those with triple-negative tumor subtype.


Conclusion: Achieving pCR after neoadjuvant therapy is distinctly related to the improvement of survival, however patients who achieved a pCR, women younger than 50 years of age and those with stage III/IV disease have a higher risk of developing distant metastasis.

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Authors

Rufina Soomro
rufina.soomro@hotmail.com (Primary Contact)
Rabab Zehra
Author Biography

Rabab Zehra, Liaquat National Hospital and Medical College, Karachi. Pakistan

Chief Resident 

Department of general and Breast surgery

 

1.
Soomro R, Zehra R. Impact of Pathological Complete Response in Breast Cancer Following Neoadjuvant Therapy on Patient’s Outcome. Arch Breast Cancer [Internet]. 2023 Oct. 31 [cited 2024 Jun. 16];10(4):331-9. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/743

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