Breast Cancer Risk Factors in Patients With Endometriosis

Bita Eslami (1), Sadaf Alipour (2), Nafsa Khazaei (3), Mahdi Sepidarkish (4), Ashraf Moini (5)
(1) Breast Disease Research Center (BDRC), Tehran University of Medical Sciences, Tehran, Iran., Iran, Islamic Republic of,
(2) Department of Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(3) Department of Microbiology, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(4) Department of Epidemiology and Reproductive Health, Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran, Iran, Islamic Republic of,
(5) Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Gynecology and Obstetrics, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Department of Endocrinology and Female Infertility at Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran, Iran, Islamic Republic of

Abstract

Background: Endometriosis is a common chronic inflammatory, estrogen-dependent disease with characteristics similar to cancer. Epidemiological studies of the association between endometriosis and breast cancer have yielded inconsistent results. The present study aimed to investigate the association between endometriosis and breast cancer risk factors.
Methods: This case-control study (with 222 persons in each group) was conducted in Arash Women's Hospital from 2014 to 2017. Women with laparoscopically proven endometriosis were considered as cases. Controls were selected from women who had previous laparoscopic surgery due to any reason, and the absence of endometriosis was confirmed in them.
Results: Multivariate logistic regression analysis by considering the risk factors (age, body mass index, gravidity, age at first pregnancy, age at menarche, history of breast-feeding, history of oral contraceptive and hormone use, history of miscarriage and induced abortion, breast cancer in first-degree relatives, and physical activity) revealed that endometriosis was positively association with age at first pregnancy (OR = 1.16, 95% CI: 1.08-1.25; P <?0.001), history of oral contraceptive use (OR = 3.91, 95% CI: 1.92-7.95; P <0.001), and history of hormone use (OR = 5.82, 95% CI: 2.70-12.56; P <0.001), and negatively associated with gravidity (OR = 0.61, 95% CI: 0.42-0.91; P = 0.01), and history of breast-feeding (OR = 0.37, 95% CI: 0.16-0.86; P = 0.02).
Conclusion: Women with endometriosis have some of the breast cancer risk factors in their history, and these risk factors (gravidity, age at first pregnancy, history of breast-feeding, and OCP or hormone use) can change the risk of endometriosis as they increase or decrease the risk of breast cancer.

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Authors

Bita Eslami
Sadaf Alipour
Nafsa Khazaei
Mahdi Sepidarkish
Ashraf Moini
ashraf.moieni@gmail.com (Primary Contact)
1.
Eslami B, Alipour S, Khazaei N, Sepidarkish M, Moini A. Breast Cancer Risk Factors in Patients With Endometriosis. Arch Breast Cancer [Internet]. 2018 Jun. 8 [cited 2024 Nov. 4];:76-80. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/174

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