Idiopathic Granulomatous Mastitis and History of Hypothyroidism: Intervening Data of a Prospective Multicenter Trial and Meta-Analysis of the Existing Literature IGM and Hypothyroidism

Sadaf Alipour (1), Maryam Tabatabaeian (2), Nahid Nafissi (3), Asieh Sadat Fattahi (4), Shahla Astaraki (5), Zohreh Zahernia-Shahrbabaki (6), Azadeh Jabbari-Nooghabi (7), Najmeh Dabbagh (8), Azin Saberi (9), Khadije Maajani (10), Azadeh Abdollahi (11), Fatemeh Tavakoli (12), Reihane Tahery-Mehr (13), Maryam Sarkardeh (14), Shamila Razavi (15), Manila Jafarzadeh (16), Bita Eslami (17), Maryam Gharini-Ahmadi (18), Azita Mazinani (19), Behnaz Khajeh-Ali-Beiki (20), Marzieh Orouji (21), Azam Salati (22), Ramesh Omranipour (23)
(1) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran./ Department of Surgery, Arash Women’s Hospital, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(2) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(3) Rasoul Akram Hospital Clinical Research Development Center (RCRDC), Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(4) Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Iran, Islamic Republic of,
(5) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(6) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(7) Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Iran, Islamic Republic of,
(8) Cancer Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(9) Department of Surgery, Arash Women’s Hospital, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(10) Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(11) Department of Surgery, Arash Women’s Hospital, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(12) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(13) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(14) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(15) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(16) Clinical Research Department, Cancer research Center, Motamed Cancer Institute, ACECR, Tehran, Iran., Iran, Islamic Republic of,
(17) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran. , Iran, Islamic Republic of,
(18) Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(19) Clinical Research Department, Cancer research Center, Motamed Cancer Institute, ACECR, Tehran, Iran., Iran, Islamic Republic of,
(20) Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(21) Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(22) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(23) Breast Disease Research Center (BDRC), Cancer Institute, Tehran University of medical Sciences, Tehran, Iran/Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of

Abstract

Background: Idiopathic granulomatous mastitis (IGM) is a rare benign breast disease that mostly occurs in reproductive ages in parous women. Hormonal, autoimmune, and microbial causes have been implicated as causes. We carried out this prospective study to investigate the reproductive factors and underlying disease states in IGM.


Methods: This study was conducted in two phases. In the first phase, we evaluated the reproductive factors, anthropometric parameters and past medical histories of participants of an ongoing multicentric clinical trial. In the second phase, we performed an extensive review of the literature for studies that had considered patients with a histologic-proven diagnosis of IGM without date limitations, and extracted the data about parity, breastfeeding, oral contraceptive pill use and past medical histories. We then carried out a meta-analysis.


Results:  Data of 123 patients were included. The mean age was 35.11±7.07 years, and the mean body mass index was 27.41±4.74. Overall, %93.8, 90.27% and 28.7% of patients were parous, had breastfed, and had used OCP, respectively. Hypothyroidism represented the most common (18.94%) previous medical disease. We included 89 studies in our search. Considering these studies and ours, the pooled prevalence of rates of parity, breastfeeding and oral contraceptive pill consumption were 96%, 89%, and 29%; and the pooled prevalence of hypothyroidism, diabetes and hypertension were 9%, 5% and 5%, respectively. Although not exactly comparable, these rates of hypothyroidism were higher than those reported in women in the general population (4.2% in one large study in Iran).


Conclusion: Our study suggests a possible relation between a past history of hypothyroidism and IGM. We propose a study that investigates the occurrence of IGM in some large cohorts of healthy women, and the retrospective assessment of thyroid tests in the primary serum samples.

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Authors

Sadaf Alipour
Maryam Tabatabaeian
Nahid Nafissi
Asieh Sadat Fattahi
Shahla Astaraki
Zohreh Zahernia-Shahrbabaki
Azadeh Jabbari-Nooghabi
Najmeh Dabbagh
Azin Saberi
Khadije Maajani
Azadeh Abdollahi
Fatemeh Tavakoli
Reihane Tahery-Mehr
Maryam Sarkardeh
Shamila Razavi
Manila Jafarzadeh
Bita Eslami
Maryam Gharini-Ahmadi
Azita Mazinani
Behnaz Khajeh-Ali-Beiki
Marzieh Orouji
Azam Salati
Ramesh Omranipour
Omranipour@sina.tums.ac.ir (Primary Contact)
1.
Alipour S, Tabatabaeian M, Nafissi N, Fattahi AS, Astaraki S, Zahernia-Shahrbabaki Z, Jabbari-Nooghabi A, Dabbagh N, Saberi A, Maajani K, Abdollahi A, Tavakoli F, Tahery-Mehr R, Sarkardeh M, Razavi S, Jafarzadeh M, Eslami B, Gharini-Ahmadi M, Mazinani A, Khajeh-Ali-Beiki B, Orouji M, Salati A, Omranipour R. Idiopathic Granulomatous Mastitis and History of Hypothyroidism: Intervening Data of a Prospective Multicenter Trial and Meta-Analysis of the Existing Literature: IGM and Hypothyroidism. Arch Breast Cancer [Internet]. 2022 Dec. 23 [cited 2024 Apr. 25];10(1):38-47. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/647

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