Profile and Features of Breast Cancer in HIV Positive and Negative Patients at Mankweng Academic Hospital, Limpopo Province, South Africa

Mirza Bhuiyan (1)
(1) Department of General Surgery, Mankweng Hospital, Faculty of Health Science, University of Limpopo, South Africa, South Africa

Abstract

Background: HIV and breast cancer are a major global burden of disease for women. There were 35 million people infected with HIV in 2013 and over 70% of whom lived in sub-Saharan Africa. Breast cancer is the leading form of cancer affecting South African women. The main aim of this study was to better understand the profile and features of breast cancer in HIV-positive and negative patients in the Limpopo province, South Africa. 


Methods: This is a retrospective cross sectional descriptive quantitative study designed to analyse the profile of all patients with breast cancers who attended at Mankweng Breast Oncology Clinic from July 2020 to December 2021. 


Results: Total of 205 patients. The HIV-positive group consisted of 43 patients and the HIV-negative group of 162 patients. Age range: 20-90 years, mean age: 51, mean age of HIV-positive group: 46.6(30-79) years and HIV-negative 52.4 (20-90) years. Early stage (0, I & II) included 46 patients and late stage (III & IV) 159 patients. In the HIV-negative group (162) patients 36(22%) presented with early stages and 126(78%) in the late stages. The HIV-positive group (43) contained 10(23%) patients in the early stage and 33(77%) in the late stage. 


Conclusion: In this study the mean age of HIV-positive patients was lower than the mean age of HIV-negative patients (46.6 vs 52.4). Triple negative molecular subtype breast cancer was more present in HIV-positive patients than in HIV-negative patients (24.2% vs14.4%). HIV-positive patients demonstrated a higher grade 3(47%), while HIV-negative patients had more grade 2(62%).

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References

Cubasch H, Joffe M, Hanisch R, Schuz J, Neugut AI, Karstaedt A, et al. Breast cancer characteristics and HIV among 1,092 women in Soweto, South Africa. Breast Cancer Res Treat. 2013;140(1):177-86; doi: 10.1007/s10549-013-2606-y.

Mayosi BM, Flisher AJ, Lalloo UG, Sitas F, Tollman SM, Bradshaw D. The burden of non-communicable diseases in South Africa. Lancet 2009.12;374(9693):934-47. doi: 10.1016/S0140-6736(09)61087-4.

UNAIDS: Gap Report Available from: http://www.unaids.org/en/resources/campaigns/2014/2014gapreport/gapreport

Statistics South Africa. Mid-year population estimates: 2021. Pretoria: StatsSA, 2021. Available from: http://www.statssa.gov.za/publications/P0302/P03022021.pdf

Shiels MS, Pfeiffer RM, Gail MH, Hall HI, Jianmin L, Chaturvedi AK, et al. Cancer Burden in the HIV-infected Population in the United States. JNCI: J Natl Cancer Inst. 2011;103(9):753-62. doi: 10.1093/jnci/djr076.

Reddy P, Ebrahim S, Singh B, Ramklass S, Buccimazza I. Breast Cancer and HIV: a South African perspective and a critical review of the literature. S Afr J Surg. 2017;55(1):10-15.

Bevers TB, Helvie M, Bonaccio E, Calhoun KE, Daly MB, Farrar WB, et al. Breast Cancer Screening and Diagnosis, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2018;16(11):1362-1389. doi: 10.6004/jnccn.2018.0083.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidencve and mortality worldwide for 36 cancers in 185 countries. CA: A cancer journal for clinicians. 2018:68(6): 394-424. doi: 10.3322/caac.21492.

National Cancer Registry (NCR) South Africa (2019). Available from: https://cansa.org.za/files/2022/03/NCR_Path_2019_Full_Report_8dec2021.pdf

Grover S, Narasimhamurthy M, Bhatia R, Benn C, Fearnhead K, Rate W, et al. Comparing breast cancer characteristics across sub-Saharan Africa and the United States. Eur J Cancer. 2018 Apr 1;92:S155. doi: 10.1016/S0959-8049(18)30692-0.

Oluogun WA, Adedokun KA, Oyenike MA, Adeyeba OA. Histological classification, grading, staging, and prognostic indexing of female breast cancer in an African population: A 10-year retrospective study. Int J Health Sci (Qassim) 2019;13(4):3-9]

Mavhungu R, Bhuiyan M, Ooko F. Profile of patients seen at Pietersburg and Mankweng breast cancer clinics in Limpopo. S Afr Med J. 2021 Dec 1;111(11b):1129-1131. doi: 10.7196/SAMJ.2021.v111i11b.16108.

Langenhoven L, Barnardt P, Neugut AI, Jacobson JS. Phenotype and Treatment of Breast Cancer in HIV-Positive and -Negative Women in Cape Town, South Africa. J Glob Oncol. 2016 Mar 30;2(5):284-291. doi: 10.1200/JGO.2015.002451.

Edge J, Buccimazza I, Cubasch H, Panieri E. The challenges of managing breast cancer in the developing world - a perspective from sub-Saharan Africa. S Afr Med J. 2014 May;104(5):377-9. doi: 10.7196/samj.8249.

Grover S, Martei YM, Puri P, Prabhakar P, Mutebi M, Balogun OD, et al. Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship. J Glob Oncol. 2018 Sep;4:1-11. doi: 10.1200/JGO.2016.006585.

Vanderpuye V, Grover S, Hammad N, PoojaPrabhakar, Simonds H, Olopade F, et al. An update on the management of breast cancer in Africa. Infect Agent Cancer. 2017 Feb 14;12:13. doi: 10.1186/s13027-017-0124-y.

Bhuiyan M, Maele M, Mavhungu R; Ooko F. Breast cancer: Factors influencing late-stage presentation at the Mankweng Hospital breast cancer clinic, Polokwane, Limpopo Province, South Africa. S Afr Med J 2022;112(11b):906-910. doi: 10.7196/SAMJ.2022.v112i11b.16834.

Pantanowitz L, Dezube BJ. Evolving spectrum and incidence of non-AIDS-defining malignancies. Curr Opin HIV AIDS. 2009;4(1):27-34; doi: 10.1097/COH.0b013e32831a7259.

Frierson HF Jr, Wolber RA, Berean KW, Franquemont DW, Gaffey MJ, Boyd JC, et al. Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma. Am J Clin Pathol. 1995 Feb;103(2):195-8. doi: 10.1093/ajcp/103.2.195.

Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B, Senn HJ, et al. Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol. 2011;22(8):1736-47; doi: 10.1093/annonc/mdr304.

van Zyl N, Minné C, Mokone DH. Human immunodeficiency virus infection in breast cancer patients: The prevalence thereof and its effect on breast cancer characteristics at Dr. George Mukhari Academic Hospital Breast Clinic, Ga-Rankuwa, South Africa. SA J Radiol. 2018 Aug 30;22(2):1361. doi: 10.4102/sajr.v22i2.1361.

Bhatia RK, Narasimhamurthy M, Martei YM, Prabhakar P, Hutson J, Chiyapo S, et al. Report of clinico-pathological features of breast cancer in HIV-infected and uninfected women in Botswana. Infect Agent Cancer. 2019 Oct 21;14:28. doi: 10.1186/s13027-019-0245-6.

Andrade AC, Luz PM, Veloso VG, Cardoso SW, Moreira RI, Grinsztejn B, et al. Breast cancer in a cohort of human immunodeficiency virus (HIV)-infected women from Rio de Janeiro, Brazil: a cases series report and an incidence rate estimate. Braz J Infect Dis. 2011;15(4):387-933; doi:10.1590/s1413-86702011000400016.

Ruiz M, Davis H. Breast Cancer in HIV-Infected Patients: A Retrospective Single-Institution Study. J Int Assoc Physicians AIDS Care (Chicago, Ill: 2002). 2011;10(1):30-4. doi: 10.1177/1545109710385002.

Calabresi A, Ferraresi A, Vavassori A, Castelli F, Quiros-Roldan E. Breast cancer among human immunodeficiency virus (HIV)- infected patients: the experience in Brescia, Northern Italy. Braz J Infec Dis. 2012;16(4):396-7; doi: 10.1016/j.bjid.2012.06.001.

Kohler RE, Moses A, Krysiak R, Liomba NG, Gopal S. Pathologically confirmed breast cancer in Malawi: A descriptive study: Clinical profile of breast cancer. Malawi Med J 2015;27(1):10-12. doi: 10.4314/mmj.v27i1.3.

Fragomeni SM, Sciallis A, Jeruss JS. Molecular Subtypes and Local-Regional Control of Breast Cancer. Surg Oncol Clin N Am. 2018 Jan;27(1):95-120. doi: 10.1016/j.soc.2017.08.005.

Sheppard VB, Cavalli LR, Dash C, Kanaan YM, Dilawari AA, Horton S, et al. Correlates of Triple Negative Breast Cancer and Chemotherapy Patterns in Black and White Women With Breast Cancer. Clin Breast Cancer. 2017 Jun;17(3):232-238. doi: 10.1016/j.clbc.2016.12.006.

Authors

Mirza Bhuiyan
bhuiyanmirza@gmail.com (Primary Contact)
1.
Bhuiyan M. Profile and Features of Breast Cancer in HIV Positive and Negative Patients at Mankweng Academic Hospital, Limpopo Province, South Africa. Arch Breast Cancer [Internet]. 2023 Oct. 31 [cited 2024 Jun. 16];10(4):370-6. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/801

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