Physiological mechanisms of exercise related to prevention and treatment of breast cancer: A review Exercise for prevention and treatment of BC

Maryam koushkie Jahromi (1), Ahmadreza Dehghani (2), Mohammadhosein Ghasemi (3)
(1) Shiraz University of Medical Sciences, Shiraz, Iran, Iran, Islamic Republic of,
(2) Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran, Iran, Islamic Republic of,
(3) Department of Sport Sciences, Shiraz University, Iran, Iran, Islamic Republic of


Background: Considering limitations related to intensity, duration, and mode of exercise and possible physiological mechanisms, this study aimed to summarize the physiological mechanisms emphasizing inflammation, angiogenesis, and immunology of different exercises related to prevention and treatment of breast cancer.

Methods: In the current review study, different platforms were analyzed including PubMed, Scopus, Cochrane, Embase, Web of Science, Science Direct, Google Scholar, and Research Gate as well as Iranian databases such as Scientific Information Database (SID) and Magiran. The data was reviewed until May 2024. Search keywords included “exercise", "sport”, “physical exercise”, “intensity, training”, “breast cancer”, “inflammation”, “angiogenesis”,” immunology”, and “physiological mechanisms”.

Results:  Among several proposed mechanisms, inflammation, immunity and angiogenesis have been mentioned as important indices but there are ambiguities regarding the influence of different intensities and durations of exercise on breast cancer prevention and treatment. Other effective factors such as the effect of exercise on gene regulation and some other mechanisms have been proposed as possible mediators.

Conclusion: According to some previous studies, aerobic exercise induces positive effects on preventing and treating breast cancer through reducing inflammation, improving angiogenesis, and enhancing immunological mechanisms. Regarding duration and intensity, long term regular exercise (>8 weeks), in the form of aerobic and especially high intensity interval training (HIIT) reduces inflammation. while the effect of short-term exercise training is not clear yet and high intensity exercise may induce suppressing effects on the immune system. Therefore, the effect of intensity and duration of exercise on physiological mechanisms must be clarified. 

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Maryam koushkie Jahromi (Primary Contact)
Ahmadreza Dehghani
Mohammadhosein Ghasemi
koushkie Jahromi M, Dehghani A, Ghasemi M. Physiological mechanisms of exercise related to prevention and treatment of breast cancer: A review: Exercise for prevention and treatment of BC. Arch Breast Cancer [Internet]. [cited 2024 Jul. 14];11(3). Available from:

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