Mindfulness, Self-Compassion, and Perceived Stress in Women With Breast Cancer: A Systematic Review of Quantitative Studies
Abstract
Objectives
To identify the relationships between mindfulness, self-compassion, and perceived stress among breast cancer survivors, and to evaluate the extent to which self-compassion mediates the relationship between mindfulness and perceived stress.
Methods
This study was registered with the International Prospective Register of Systematic Reviews. A systematic literature search was conducted in the Scopus, Medline, ProQuest, PsycINFO, and Web of Science databases. The review included only quantitative studies, published in English between 2015 and 2025, that involved women with breast cancer and examined the relationship between mindfulness, self-compassion, and perceived stress in dyads, regardless of geographical location. Two reviewers independently extracted data and evaluated the methodological quality of each study using the Joanna Briggs Institute tool. The findings were then analyzed and integrated using narrative synthesis.
Results
Twelve studies were selected from a total of 1,302. They employed the Perceived Stress Scale, the Self-Compassion Scale (short and long forms), the Five-Facet Mindfulness Questionnaire, and the Cognitive and Affective Mindfulness Scale. Perceived stress was generally negatively associated with mindfulness and self-compassion. Studies involving self-compassion meditation were limited. Sociodemographic and baseline characteristics were commonly included as covariates.
Conclusion
This systematic review highlights the significance of mindfulness and self-compassion in perceived stress and notes that their combined effects have been only minimally explored. Findings may assist nursing researchers in tailoring mindfulness and self-compassion interventions to reduce perceived stress through implementation by nurses in clinical settings. Future studies should also refine mindfulness measures to enhance their applicability and effectiveness in the context of breast cancer.
References
WHO. Breast Cancer [Internet]. 2024 [cited 2025 Jun 2]. Breast cancer. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer
Alagizy HA, Soltan MR, Soliman SS, Hegazy NN, Gohar SF. Anxiety, depression and perceived stress among breast cancer patients: single institute experience. Middle East Curr Psychiatry. 2020 Dec;27(1):29. doi:10.1186/s43045-020-00036-x
Al-Ghareeb S, Asiri MY, Aboshaiqah A. The relationship between perceived stress, mindfulness, and sociodemographics among breast cancer patients in Saudi Arabia: a cross-sectional study. Discov Psychol. 2025 Dec 7. doi:10.1007/s44202-025-00552-z
Kingsley A, Nta O, Olukayode O, Olose E. Psychological complications of chemotherapy and management among cancer patients: A review for physcian education in Nigeria. Onkologia i Radioterapia [Internet]. 2024 [cited 2025 Sep 18];18(9). Available from: https://www.oncologyradiotherapy.com/abstract/psychological-complications-of-chemotherapy-and-management-among-cancer-patients-a-review-for-physcian-education-in-nige-1099547.html
Wang HQ, Lin H, Liu B. Research progress on the psychological burden and intervention measures in cancer patients. Front Psychiatry. 2024 Jun 13;15:1408762. doi:10.3389/fpsyt.2024.1408762 PubMed PMID: 38938456; PubMed Central PMCID: PMC11208330.
Bartlett L, Buscot MJ, Bindoff A, Chambers R, Hassed C. Mindfulness Is Associated With Lower Stress and Higher Work Engagement in a Large Sample of MOOC Participants. Front Psychol. 2021 Sep 10;12. doi:10.3389/fpsyg.2021.724126
Naskar S, Dixit S, Varadharasu S, Pattnaik JI, Singh R. Effect of mindfulness-based intervention on perceived stress among breast cancer patients undergoing chemotherapy. J Family Med Prim Care. 2024 Aug;13(8):2934–40. doi:10.4103/jfmpc.jfmpc_1713_23 PubMed PMID: 39228637; PubMed Central PMCID: PMC11368353.
Sakki SE, Penttinen HM, Hilgert OM, Volanen SM, Saarto T, Raevuori A. Mindfulness is associated with improved psychological well-being but no change in stress biomarkers in breast cancer survivors with depression: a single group clinical pilot study. BMC Womens Health. 2022 Dec 12;22(1):518. doi:10.1186/s12905-022-02116-y PubMed PMID: 36510201; PubMed Central PMCID: PMC9743600.
Tenorio do Amaral PG, Tosello GT, Silva Filho PP, Nahas EAP, Brito Buttros D de A. Effectiveness of mindfulness-based interventions on quality of life in women breast cancer survivors: a systematic review and meta-analysis. The Breast. 2026 Apr 1;86:104701. doi:10.1016/j.breast.2026.104701
Wang J, Drossaert CHC, Knevel M, Chen L, Bohlmeijer ET, Schroevers MJ. The Mechanisms Underlying the Relationship Between Self‐Compassion and Psychological Outcomes in Adult Populations: A Systematic Review. Stress Health. 2025 Aug;41(4):e70090. doi:10.1002/smi.70090 PubMed PMID: 40719190; PubMed Central PMCID: PMC12302336.
Osama H, Rabea HM, Abdelrahman MA. The impact of mindfulness-based stress reduction on psychological health among patients with chronic diseases during COVID-19 outbreak lockdown. Beni-Suef Univ J Basic Appl Sci. 2023 May 20;12(1):50. doi:10.1186/s43088-023-00389-2
Menon R, Saranya TS. Impact of mindfulness practices to improve quality of life and mental health of persons diagnosed with breast cancer: a systematic review. Front Psychol. 2025;16:1641751. doi:10.3389/fpsyg.2025.1641751 PubMed PMID: 41394068; PubMed Central PMCID: PMC12697308.
Çetiner E, Turan Kavradım S. Online self-compassion-based interventions on patient outcomes in patients with cancer: a systematic review. Support Care Cancer. 2026 Apr 23;34(5):457. doi:10.1007/s00520-026-10660-8
Whittemore R, Knafl K. The integrative review: updated methodology. Journal of Advanced Nursing. 2005 Dec 1;52(5):546–53. doi:10.1111/j.1365-2648.2005.03621.x
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 Statement: an Updated Guideline for Reporting Systematic Reviews. BMJ (Online). 2021;372(Journal Article):n71–n71. doi:10.1136/bmj.n71
PRISMA statement [Internet]. [cited 2026 Jan 21]. PRISMA 2020 flow diagram. Available from: https://www.prisma-statement.org/prisma-2020-flow-diagram
Tufanaru C, Munn Z, Aromataris E, Campbell J, Hopp L. JBI Manual for Evidence Synthesis. In: Chapter 3: Systematic reviews of effectiveness [Internet]. 2020 [cited 2026 Jan 17]. Available from: https://synthesismanual.jbi.global
Boyle Chloe, Stanton AL, Ganz PA, Crespi CM, Bower JE. Improvements in emotion regulation following mindfulness meditation: Effects on depressive symptoms and perceived stress in younger breast cancer survivors. Journal of Consulting and Clinical Psychology. 2017;85(4):397–402. doi:10.1037/ccp0000186
Cheung EO, Cohn MA, Dunn LB, Melisko ME, Morgan S, Penedo FJ, et al. A randomized pilot trial of a positive affect skill intervention (lessons in linking affect and coping) for women with metastatic breast cancer. Psycho-Oncology. 2017;26(12):2101–8. Located at: Scopus. doi:10.1002/pon.4312
Dodds SE, Pace TW, Bell ML, Fiero M, Negi LT, Raison CL, et al. Feasibility of Cognitively-Based Compassion Training (CBCT) for breast cancer survivors: a randomized, wait list controlled pilot study. Supportive Care in Cancer. 2015 Dec;23(12):3599–608. Located at: ProQuest Central; 1727836331. doi:10.1007/s00520-015-2888-1
Lengacher CA, Gruss LF, Kip KE, Reich RR, Chauca KG, Moscoso MS, et al. Mindfulness-based stress reduction for breast cancer survivors (MBSR(BC)): evaluating mediators of psychological and physical outcomes in a large randomized controlled trial. Journal of Behavioral Medicine. 2021;44(5):591–604. Located at: Scopus. doi:10.1007/s10865-021-00214-0
Lengacher CA, Johnson-Mallard V, Post-White J, Moscoso MS, Jacobsen PB, Klein TW, et al. Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer. Psychooncology. 2009 Dec;18(12):1261–72. doi:10.1002/pon.1529 PubMed PMID: 19235193.
Lengacher CA, Reich RR, Ramesar S, Alinat CB, Moscoso M, Cousin L, et al. Feasibility of the mobile mindfulness-based stress reduction for breast cancer (mMBSR(BC)) program for symptom improvement among breast cancer survivors. Psychooncology. 2018 Feb;27(2):524–31. doi:10.1002/pon.4491 PubMed PMID: 28665541; PubMed Central PMCID: PMC7771353.
Bower JE, Crosswell AD, Stanton AL, Crespi CM, Winston D, Arevalo J, et al. Mindfulness meditation for younger breast cancer survivors: A randomized controlled trial. Cancer. 2015 Apr 15;121(8):1231–40. doi:10.1002/cncr.29194
Hoffman C, Baker B. Effects of Mindful Self-Compassion Program on Psychological Well-being and Levels of Compassion in People Affected by Breast Cancer. Altern Ther Health Med. 2023 Sep;29(6):36–41. PubMed PMID: 35648691.
Gonzalez H, Romero Retes R, Campos D, Burychka D, Diego-Pedro R, Banos R, et al. Cognitively-Based Compassion Training (CBCT ® ) in Breast Cancer Survivors: A Randomized Clinical Trial Study. Integrative Cancer Therapies. 2018;17(3):684–96. Located at: Scopus. doi:10.1177/1534735418772095
Svendsen K, Nes LS, Leithe S, Meland A, Gjelsvik YM, Børøsund E, et al. Testing two digital stress-management interventions in a randomized controlled trial of breast cancer patients. Sci Rep. 2025 Nov 6;15(1):38966. doi:10.1038/s41598-025-22889-0
Trindade IA, Ferreira C, Pinto-Gouveia J. Acceptability and preliminary test of efficacy of the Mind programme in women with breast cancer: An acceptance, mindfulness, and compassion-based intervention. Journal of Contextual Behavioral Science. 2020 Jan 1;15:162–71. doi:10.1016/j.jcbs.2019.12.005
Abdollahi A, Taheri A, Allen KA. Self‐compassion moderates the perceived stress and self‐care behaviors link in women with breast cancer. Psycho‐oncology. 2020;29(5):927–33. doi:10.1002/pon.5369
Bordbar F, Shoaei M. The Role of Cognitive Flexibility, Psychological Hardiness, and Self-Compassion in Predicting the Role of Perceived Stress in Women with Breast Cancer. ijbd. 2025 Mar 1;18(2):148–61. doi:10.61186/ijbd.18.2.148
Arefian M, Asgari-Mobarake K, Fazilatpour M, Zanguri V, Akrami M. Proposing and evaluating a model of depression, stress, resilience and spirituality in relation to pain in women with breast cancer: Investigating the mediating role of mindfulness. European Journal of Oncology Nursing. 2023 Feb 1;62:102268. doi:10.1016/j.ejon.2023.102268
Zhang JY, Zhou ,Yu-Qiu, Feng ,Zi-Wei, Fan ,Yi-Nan, Zeng ,Guang-Chun, and Wei L. Randomized controlled trial of mindfulness-based stress reduction (MBSR) on posttraumatic growth of Chinese breast cancer survivors. Psychology, Health & Medicine. 2017 Jan 2;22(1):94–109. doi:10.1080/13548506.2016.1146405 PubMed PMID: 26853191.
Zhang JY, Li SS, Meng LN, Zhou YQ. Effectiveness of a nurse-led Mindfulness-based Tai Chi Chuan (MTCC) program on Posttraumatic Growth and perceived stress and anxiety of breast cancer survivors. Eur J Psychotraumatol. 2022;13(1):2023314. doi:10.1080/20008198.2021.2023314 PubMed PMID: 35140880; PubMed Central PMCID: PMC8820790.
Zhou J, Huang X, Yuan D, Wang L, Liu M, Jiang X, et al. The connection between mindfulness levels and life satisfaction among breast cancer patients: the sequential mediating effects of body appreciation and stress perception. PeerJ. 2025 Dec 18;13:e20485. doi:10.7717/peerj.20485
Ryu H, You SN, Oh S, Kim B, Kim JH, Kim IA. Evaluating the Effects of Mindfulness-Based Self-Help via an OTT Platform on Breast Cancer Patients Undergoing Radiotherapy: A Prospective Nonrandomized Controlled Trial. Cancer Res Treat. 2024 Nov 25;57(3):741–8. doi:10.4143/crt.2024.955
Krutchan N, Skulphan S, Thapinta D, Thungjaroenkul P, Saengthong S. Factors predicting self-compassion among patients with breast cancer undergoing chemotherapy in Thailand: A cross-sectional study. Belitung Nurs J. 2024 Jun 28;10(3):341–50. doi:10.33546/bnj.3359 PubMed PMID: 38947302; PubMed Central PMCID: PMC11211746.
Pehlivan M, Eyi S. The Impact of Mindfulness-Based Meditation and Yoga on Stress, Body Image, Self-esteem, and Sexual Adjustment in Breast Cancer Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial. Cancer Nursing [Internet]. 2025;48(3). Available from: https://journals.lww.com/cancernursingonline/fulltext/2025/05000/the_impact_of_mindfulness_based_meditation_and.6.aspx
Hsiao FH, Lo C, Huang CS, Kuo WH, Huang FY, Chen YT, et al. Mediating Effects of Mindfulness Compassion-based Peer Counseling Program for Breast Cancer Survivors: From Mindfulness, Compassion to Others to Depression Reduction. Psy intervention. 2025 Dec 5;35(x):Article e260814. doi:10.5093/pi2026a6
Zhang JY, Zhou YQ, Feng ZW, Fan YN, Zeng GC, Wei L. Randomized controlled trial of mindfulness-based stress reduction (MBSR) on posttraumatic growth of Chinese breast cancer survivors. Psychology, Health & Medicine. 2017 Jan 2;22(1):94–109. doi:10.1080/13548506.2016.1146405 PubMed PMID: 26853191.
Hoffman GJ, Hays RD, Shapiro MF, Wallace SP, Ettner SL. The Costs of Fall-Related Injuries among Older Adults: Annual Per-Faller, Service Component, and Patient Out-of-Pocket Costs. Health Serv Res. 2017;52(5):1794–816. Located at: Scopus. doi:10.1111/1475-6773.12554
Conversano C, Ciacchini R, Orrù G, Di Giuseppe M, Gemignani A, Poli A. Mindfulness, Compassion, and Self-Compassion Among Health Care Professionals: What’s New? A Systematic Review. Front Psychol. 2020 Jul 31;11:1683. doi:10.3389/fpsyg.2020.01683 PubMed PMID: 32849021; PubMed Central PMCID: PMC7412718.
Ding X, Zhao F, Zhu M, Wang Q, Wei S, Xue J, et al. A systematic review and meta-analysis of interventions to reduce perceived stress in breast cancer patients. Complement Ther Clin Pract. 2024 Feb;54:101803. doi:10.1016/j.ctcp.2023.101803 PubMed PMID: 38159534.
Xue P, Abdullah SMS. A Systematic Review of Mindfulness-based Stress Reduction (MBSR) and Its Effects on Mental Health and Academic Performance in University Students [Internet]. 2025. doi:10.2174/0118743501379520250716121048
Sosa-Cordobés E, Ramos-Pichardo JD, Sánchez-Ramos JL, García-Padilla FM, Fernández-Martínez E, Garrido-Fernández A. How Effective Are Mindfulness-Based Interventions for Reducing Stress and Weight? A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Dec 27;20(1):446. doi:10.3390/ijerph20010446 PubMed PMID: 36612767; PubMed Central PMCID: PMC9819465.
van Wietmarschen H, Tjaden B, van Vliet M, Battjes-Fries M, Jong M. Effects of mindfulness training on perceived stress, self-compassion, and self-reflection of primary care physicians: a mixed-methods study. BJGP Open. 2018 Nov 28;2(4):bjgpopen18X101621. doi:10.3399/bjgpopen18X101621
Authors
Copyright (c) 2026 Archives of Breast Cancer

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright©. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International License, which permits copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, except for commercial purposes.