Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis Breast Pilomatrixoma

Shokouh Taghipour Zahir (1), Fatemeh Derakhshani (2), Koorosh Rahmani (3), Seyed Mostafa Shiryazdi (4)
(1) Department of Pathology, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of,
(2) Department of Pathology, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran, Iran, Islamic Republic of,
(3) General Practitioner, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of,
(4) Department of surgery, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of

Abstract

Background: Pilomatrixoma   is a benign adnexal tumor with differentiation towards the matrix of the hair follicle and occurs mostly in the head, neck, and upper extremities of the child. Pilomatrixoma of the breast is considered a very rare tumor.


Case presentation: Herein, we present a 47-year-old woman who was referred to the surgery ward for a palpable right breast mass. Imaging studies revealed a well-circumscribed lesion categorized as BIRADs3. Because clinically the lesion was large and had a stony hard consistency so patient underwent surgery and intraoperative consultation was negative and revealed a well-defined lesion composed of basaloid cells, multinucleated giant cells admixed with bone trabeculae, and nests of ghost cells. Immunohistochemical (IHC) studies were done and the cells were positive for AE1/AE3, Beta-catenin, and BCL2 and negative for Mart1 and CD117. Based on H&E and IHC studies, pilomatrixoma of the breast tissue was confirmed.


Conclusion: Breast pilomatrixoma   is a very rare benign neoplasm that could clinically mimic malignant neoplasm and should be considered in the differential diagnosis of breast masses

Full text article

Generated from XML file

References

Tokur O, Aydin S, Seher Oztekin P, Suleyman M, Erel S, Celepli P. Pilomatrixoma of the breast in a male patient. imaging interv. 2021;1(2):44-46. doi: 10.5152/ iao.2021.21034.

Bensalah A, Benaaddach HO, Gouzi I, Haloua M, Elbouardi N, Alami B, et al. Pilomatrixoma mimicking a breast neoplasm: imaging finding in an uncommon case report. Radiol Case Rep. 2021;16(9):2357-2361. doi: 10.1016/j.radcr.2021.06.007.

Agrawal R, Kumar P. Pilomatrixoma-unveiling the ghost story: Report of 5 cases with review of the literature. Int J Case Rep Images. 2015;6(4):193-197. doi: 10.5348/ijcri-201502-CS-10053.

Pai T, Harwani SR, Patil A, Sahay A, Shet T, Parmar V, et al. Pilomatrix Carcinoma Masquerading as Breast Carcinoma. Indian J Med Paediatr Oncol. 2017;38(3):367-370. doi: 10.4103/ijmpo.ijmpo_118_16.

Kapoor A, Narayanan R, Tandon A, Santosh AK. Pilomatrixoma: An unusual cause of lump in a male breast. J Clin Ultrasound. 2018;46(3):209-211. doi: 10.1002/jcu.22503.

Gil JR, Herh SJ, Kim Y, Song MA, Kim MY, Kim E. A pilomatrixoma misdiagnosed as male breast cancer. J Korean Soc Radiol. 2016;74(3):156-159. doi: 10.3348/jksr.2016.74.3.156.

Sood N, Raj B. Pilomatrixoma male breast, mimicking breast carcinoma-A rare case. Indian J Pathol Microbiol. 2021;64(1):204-205. doi: 10.4103/IJPM.IJPM_194_20.

Clark A, Leddy R, Spruill L, Cluver A. Pilomatrixoma, a Rare Mimicker of Male Breast Cancer. J Clin Imaging Sci. 2019 Nov 6;9:46. doi: 10.25259/JCIS_64_2019.

Fonseca RPL, Andrad Filho JS, Araujo IC, Silva Filho AF, Pereira NA, Carvalho EES, et al. Pilomatrixoma: calcifying epithelioma of Malherbe. Rev Bras Ci. Plast.2012;27(4):605-610.

Nori J, Abdulcadir D, Giannotti E, Calabrese M. Pilomatrixoma of the breast, a rare lesion simulating breast cancer: a case report. J Radiol Case Rep. 2013:1;7(10):43-50. doi: 10.3941/jrcr.v7i10.1651.

Hubeny CM, Sykes JB, O'Connell A, Dogra VS. Pilomatrixoma of the adult male breast: a rare tumor with typical ultrasound features. J Clin Imaging Sci. 2011;1:12. doi: 10.4103/2156-7514.76690.

Rachakonda T, Kacker A, Koizumi J. Pediatric pilomatrixoma of the preauricular region. Acta Cytol. 2010;54(5):724-6. doi: 10.1159/000325241.

Mitteldorf CATDS, Vilela RS, Fugimori ML, de Godoy CD, Coudry RA. Novel Mutations in Pilomatrixoma, CTNNB1 p.s45F, and FGFR2 p.s252L: A Report of Three Cases Diagnosed by Fine-Needle Aspiration Biopsy, with Review of the Literature. Case Rep Genet. 2020, 29;2020:8831006. doi: 10.1155/2020/8831006.

Martins M, Lucarelli A, Aldrighi J, Forattini A. A case report of calcifying epithelioma of Malherbe (pilomatrixoma) mimicking breast carcinoma in male patient. Case reports in clinical medicine. 2014;3:276-180. doi: 10.4236/crcm.2014.35063.

Lozzi GP, Soyer HP, Fruehauf J, Massone C, Kerl H, Peris K. Giant pilomatrixoma. Am J Dermatopathol. 2007;29(3):286-9. doi: 10.1097/DAD.0b013e318053db45.

Bhuta R, Wring G, Lau Q, Bhuta S. Metastatic malignant pilomatrixoma: a case report and review of the literature. Pathology. 2009;41(1):1-87. doi: 10.1097/01268031-200941001-00124.

Malgras B, Durand X, Camparo P, Houlgatte A. Pilomatricome scrotal: à propos d'un cas et revue de la littérature [Scrotal pilomatrixoma: a case report and review of the literature]. Prog Urol. 2010;20(6):469-71. French. doi: 10.1016/j.purol.2009.10.007.

Hamilton A, Young GI, Davis RI. Pilomatrixoma mimicking breast carcinoma. Br J Dermatol. 1987;116(4):585-6. doi: 10.1111/j.1365-2133.1987.tb05883.x.

Authors

Shokouh Taghipour Zahir
Fatemeh Derakhshani
f.derakhshani93@gmail.com (Primary Contact)
Koorosh Rahmani
Seyed Mostafa Shiryazdi
1.
Taghipour Zahir S, Derakhshani F, Rahmani K, Shiryazdi SM. Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis: Breast Pilomatrixoma. Arch Breast Cancer [Internet]. 2024 May 1 [cited 2024 Dec. 10];11(2):213-7. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/833

Article Details