Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis Breast Pilomatrixoma

Shokouh Taghipour Zahir (1), Fatemeh Derakhshani (2), Koorosh Rahmani (3), Seyed Mostafa Shiryazdi (4)
(1) Department of Pathology, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of,
(2) Department of Pathology, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran, Iran, Islamic Republic of,
(3) General Practitioner, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of,
(4) Department of surgery, Shahid Sadoughi University of Medical sciences and Health Services,Yazd, Iran , Iran, Islamic Republic of


Background: Pilomatrixoma   is a benign adnexal tumor with differentiation towards the matrix of the hair follicle and occurs mostly in the head, neck, and upper extremities of the child. Pilomatrixoma of the breast is considered a very rare tumor.

Case presentation: Herein, we present a 47-year-old woman who was referred to the surgery ward for a palpable right breast mass. Imaging studies revealed a well-circumscribed lesion categorized as BIRADs3. Because clinically the lesion was large and had a stony hard consistency so patient underwent surgery and intraoperative consultation was negative and revealed a well-defined lesion composed of basaloid cells, multinucleated giant cells admixed with bone trabeculae, and nests of ghost cells. Immunohistochemical (IHC) studies were done and the cells were positive for AE1/AE3, Beta-catenin, and BCL2 and negative for Mart1 and CD117. Based on H&E and IHC studies, pilomatrixoma of the breast tissue was confirmed.

Conclusion: Breast pilomatrixoma   is a very rare benign neoplasm that could clinically mimic malignant neoplasm and should be considered in the differential diagnosis of breast masses

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Shokouh Taghipour Zahir
Fatemeh Derakhshani (Primary Contact)
Koorosh Rahmani
Seyed Mostafa Shiryazdi
Taghipour Zahir S, Derakhshani F, Rahmani K, Shiryazdi SM. Breast Pilomatrixoma in a 47-year-old Woman: Pathological and Radiological Diagnosis: Breast Pilomatrixoma. Arch Breast Cancer [Internet]. 2024 May 1 [cited 2024 Jun. 16];11(2):213-7. Available from:

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