Familial Fibroadenoma of Breast: A Case Series of Uncommon Presentation of a Common Disease Familial Fibroadenoma

Mahim Koshariya (1), Vidhu Shekhar Khare (2), Badri Patel (3), Shikha Shukla (4), Aryesh K Gupta (5), Mohammad Riyaz (6), Gyanendra Kumar (7)
(1) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India,
(2) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India,
(3) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India,
(4) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India,
(5) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India,
(6) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India,
(7) Department of General Surgery, Gandhi Medical College & Hamidia Hospital, Bhopal, India, India

Abstract

Background: Fibroadenoma is the second most common tumour in the breast (after carcinoma) and is the most common tumour in women younger than 30 years. Multiple fibroadenomas (more than five lesions in one breast) are very uncommon and are considered disease. Familial bilateral multiple fibroadenoma is an exceedingly rare presentation with only one such case described earlier in medical literature where three siblings had multiple bilateral breast fibroadenomas. We report a case series of familial fibroadenomas present in four siblings, along with one case presenting with bilateral multiple fibroadenoma, which is first in the medical literature.
Case Presentation: Fine needle Aspiration were suggestive of bilateral multiple fibroadenoma. Upon surgery, 10 fibroadenomas were removed from the right breast and 9 fibroadenomas were removed from the left breast. Histopathological examination was consistent with fibroadenoma with myxomatous change.
Conclusion: Familial fibroadenoma of the breast is an exceedingly rare presentation of a very common tumour. This was the first reported case of 4 siblings having familial fibroadenoma. Further studies are required to investigate the familial nature of this disorder.

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References

Kelly K. Hunt EAM. Diseases of the Breast. Sabiston textbook of surgery : the biological basis of modern surgical practice. 20 ed: Elsevier; 2016. p. 820-64.

Kelly K. Hunt JFRR, and Kirby I. Bland. The Breast. In: F. Charles Brunicardi, Dana K. Andersen, Timothy R. Billiar, David L. Dunn, Lillian S. Kao, John G. Hunter, Jeffrey B. Matthews, Raphael E. Pollock. The Breast. Schwartz's principles of surgery. 11 ed: McGraw-Hill; 2019. p. 497-564.

Sainsbury. RC. The Breast. Bailey & Love's short practice of surgery. 27 ed: CRC Press; 2018. p. 860-82.

Naraynsingh V, Raju GC. Familial bilateral multiple fibroadenomas of the breast. Postgrad Med J. 1985;61(715):439-40. doi: 10.1136/pgmj.61.715.439.

Panda SK, Patro B, Mishra J, Dora RK, Subudhi BSK. Multiple fibroadenomas in bilateral breasts of a 46-year-old Indian woman - A case report. Int J Surg Case Rep. 2014;5(5):262-4. doi: 10.1016/j.ijscr.2013.12.013.

Nassar A, Visscher DW, Degnim AC, Frank RD, Vierkant RA, Frost M, et al. Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study. Breast Cancer Res Treat. 2015;153(2):397-405. doi: 10.1007/s10549-015-3535-8.

Li J, Humphreys K, Ho PJ, Eriksson M, Darai-Ramqvist E, Lindström LS, et al. Family History, Reproductive, and Lifestyle Risk Factors for Fibroadenoma and Breast Cancer. JNCI Cancer Spectr. 2018;2(3):pky051. doi: 10.1093/jncics/pky051.

Wiegenstein L, Tank R, Gould VE. Multiple breast fibroadenomas in women on hormonal contraceptives. N Engl J Med. 1971;284(12):676. doi: Not Available

Chintamani, Khandelwal R, Tandon M, Yashwant K, Kulshreshtha P, Aeron T, et al. Carcinoma developing in a fibroadenoma in a woman with a family history of breast cancer: a case report and review of literature. Cases J. 2009;2:9348. doi: 10.1186/1757-1626-2-9348.

Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, et al. Genetics and genomics of breast fibroadenomas. J Clin Pathol. 2018;71(5):381-7. doi: 10.1136/jclinpath-2017-204838.

da Silva EM, Beca F, Sebastiao APM, Murray MP, Silveira C, Da Cruz Paula A, et al. Stromal MED12 exon 2 mutations in complex fibroadenomas of the breast. J Clin Pathol. 2020. doi: 10.1136/jclinpath-2020-207062.

Authors

Mahim Koshariya
Vidhu Shekhar Khare
vidsfriendcircle@gmail.com (Primary Contact)
Badri Patel
Shikha Shukla
Aryesh K Gupta
Mohammad Riyaz
Gyanendra Kumar
1.
Koshariya M, Khare VS, Patel B, Shukla S, Gupta AK, Riyaz M, Kumar G. Familial Fibroadenoma of Breast: A Case Series of Uncommon Presentation of a Common Disease: Familial Fibroadenoma. Arch Breast Cancer [Internet]. 2022 Mar. 4 [cited 2024 Apr. 23];9(2):236-9. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/477

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