The Relationship Between Breast Cancer and VDR Gene Polymorphisms

Hengameh Mozaffarizadeh (1), Mohammadreza Hakimian (2), Mansoor Salehi (3), Elham Moazam (4), Mohaddeseh Behjati (5), Mahtab Keshvari (6), Faribourz Mokarian (7)
(1) Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of,
(2) Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of,
(3) Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of,
(4) Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of,
(5) Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran, Iran, Islamic Republic of,
(6) Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of,
(7) Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran, Iran, Islamic Republic of
https://doi.org/10.19187/abc.20185126-31

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Vol 5, No 1: February 2018
Submitted
September 7, 2017
Published
March 29, 2018
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Abstract

Background: Vitamin D serves several cancer protective roles within the human body.Vitamin D functions through binding with the VDR encoded by VDR gene. It has been demonstrated that polymorphism in VDR gene would influence expression and/or function of the VDR protein. The researchers found that the most important VDR gene polymorphisms that are associated with tumorigenesis include Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs771236), and Apa1 (rs7975232). The purpose of this study was to assess the association between Fok1, Bsm1, and Taq1 polymorphisms and breast cancer development.
Methods: In this study, 50 patients suffering from breast cancer with less than 6 months after the diagnosis of breast cancer and 50 healthy control individuals were included. Restriction fragment length polymorphism PCR (RFLP-PCR) was used to determine the genotype of polymorphisms.
Results: Statistical results showed that among the studied polymorphisms, Tt genotypes of Taq1 polymorphism have correlations with breast cancer development (P< 0.001, OR= 5.51, 0.95 CI= 2.30-13.21).
Conclusion: The results of the present clearly demonstrated that there is a relationship between Taq1 polymorphism in VDR gene and development of breast cancer.

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Authors

Hengameh Mozaffarizadeh
Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
Mohammadreza Hakimian
Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mansoor Salehi
Department of Genetics, Isfahan University of Medical Sciences, Isfahan, Iran
Elham Moazam
Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mohaddeseh Behjati
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Mahtab Keshvari
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Faribourz Mokarian
Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mokarian@med.mui.ac.ir (Primary Contact)
1.
Mozaffarizadeh H, Hakimian M, Salehi M, Moazam E, Behjati M, Keshvari M, Mokarian F. The Relationship Between Breast Cancer and VDR Gene Polymorphisms. Arch Breast Cancer [Internet]. 2018 Mar. 29 [cited 2024 May 19];5(1):26-31. Available from: https://www.archbreastcancer.com/index.php/abc/article/view/159
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