Expression of CD44 in Triple Negative Breast Cancer and its Correlation with Prognostic Parameters Correlation of CD44 expression in TNBC

Pallavi Punhani (1), Charanjeet Ahluwalia (2), Meetu Agrawal (3), Preeti Kandwal (4)
(1) Department of Pathology, VMMC and Safdarjung Hospital , New Delhi, India, India,
(2) Department of Pathology, VMMC and Safdarjung Hospital , New Delhi, India, India,
(3) Department of Pathology, VMMC and Safdarjung Hospital , New Delhi, India, India,
(4) Department of Pathology, VMMC and Safdarjung Hospital , New Delhi, India, India

Abstract

Background: The study aims to evaluate CD44 expression as a cancer stem cell marker in Triple-negative breast cancer (TNBC) and its correlation with prognostic parameters. Evaluation of CD44 immunoexpression in TNBC is vital for understanding tumour aggressiveness and determining its prognostic value.


Methods: A hospital based cross sectional study of 50 cases of primary triple negative breast cancer patients. The tissue sections were subjected to immunohistochemical examination using CD44 antigen marker. The proportion and intensity of CD44 immunostaining was assessed and correlation with prognostic markers such as histological grade, tumor size and nodal status.


Results: CD44 expression was observed in 40% of the total cases with a statistically significant association with histological grade (p-value= 0.002). Higher CD44 expression was noticed with increasing tumour grade. However, no statistical significance was observed with respect to tumour size and nodal status.


Conclusion: The study suggests that CD44 immunoexpression may serve as a surrogate marker of BCSCs and may hold prognostic value in TNBC patients. However, further studies on larger samples are required to fully understand its role.

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Authors

Pallavi Punhani
Charanjeet Ahluwalia
Meetu Agrawal
magrawal.sjh@gmail.com (Primary Contact)
Preeti Kandwal
1.
Punhani P, Ahluwalia C, Agrawal M, Kandwal P. Expression of CD44 in Triple Negative Breast Cancer and its Correlation with Prognostic Parameters: Correlation of CD44 expression in TNBC. Arch Breast Cancer [Internet]. [cited 2024 Oct. 3];11(4). Available from: https://www.archbreastcancer.com/index.php/abc/article/view/964

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