Association of FGFR2 and TOX3 Genetic Variants With the Risk of Breast Cancer in Iranian Women

Main Article Content

Mojgan Hosseini
Massoud Houshmand
Shima Froozan

Keywords

Breast Cancer, FGFR2, TOX3, SNPs

Abstract

Background: Breast cancer is the most common cause of cancer-related death in women worldwide. Novel genetic markers for breast cancer susceptibility have been identified in population-based studies. The aim of this study was to examine the association of two single-nucleotide polymorphisms (SNPs) of FGFR2 (rs1219648) and TOX3 (rs8051542) with the risk of breast cancer in Iranian women.
Methods: Breast cancer patients (n = 126) and healthy controls (n = 160) were genotyped for SNPs in FGFR2 (rs1219648) and TOX3 (rs8051542) using the tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Also, immunohistochemical tests for human epidermal growth factor receptor-2, estrogen receptor, and progesterone receptor were carried out on breast tumor tissues.
Results: TOX3 (rs8051542) CC (OR = 1.24; 95% CI, 0.72-0.214; P < 0.001) and FGFR2 (rs1219648) GG (OR = 62.0; 95% CI, 23.63-162.66; χ2 =132.775 ; P < 0.001) polymorphism was significantly associated with breast cancer. The association was also significant between breast cancer risk and TOX3 (rs8051542) TC and FGFR2 (rs1219648) AG variants.
Conclusion: Our findings suggested that genetic variants of FGFR2 (rs1219648 AG) and TOX3 (rs8051542 TC) can be potential candidate biomarkers for breast cancer risk.

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